The alcohol dehydrogenase enzyme breaks down alcohol by removing hydrogen in two steps:
1. Alcohol dehydrogenase oxidizes alcohol to acetaldehyde
2. Acetaldehyde dehydrogenase oxidizes the acetaldehyde to acetyl CoA. These reactions produce hydrogen ions (acid). The B vitamin niacin (in its role as the coenzyme NAD) picks up these hydrogen ions (becoming NADH). Thus when alcohol is metabolized, NAD diminishes and NADH increases.
During alcohol metabolism, NAD becomes unavailable for the many other vital body processes for which it is needed, including glycolysis, the TCA cycle and the electron transport chain. Without NAD, the energy pathway is blocked, and alternative routes are taken, with serious physical consequences:
The accumulation of hydrogen atoms shifts the bodys balance toward acid. Read more...
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